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Lifestyle and distribution of cardiovascular disease risk factors in an employee populationA study was conducted on lifestyle and its consequence in the distribution of cardiovascular risk factors for coronary heart disease (CHD) in a population of 200 employees of a Rome-based governmental office. The following CHD risk factors were identified: sex, age, serum cholesterol, blood pressure, obesity, smoking habits and lack of physical exercise. The percentage distribution of risk factors in the sample was as follows: serum cholesterol: 30%; blood pressure: 19%; obesity: 9%; lack of exercise: 75%; smoking: 39%. The average daily energy intake was 9.71 MJ (2324 kcal), higher than this population's established requirements; the protein intake was al so found to be high, due to excessive consumption of animal foods.
In females, a positive correlation was observed between serum cholesterol and age, serum lipids and percentage of fat mass; in males, a correlation was observed with serum lipids and triglycerides. No significant correlations were observed between risk factors, with the exception of a marked connection of serum cholesterol with age in females.C. Del Balzo, R. D' Arcangelo: Lifestyle and distribution of cardiovascular disease risk factors in an employee population. Int J Food Sciences and Nutr 1994, 45, 301-6. Non-pharmacological control of plasma cholesterol levelsThe importance of non-pharmacological control of plasma cholesterol levels in the population is increasing, along with the number of subjects whose plasma lipid levels are non-optimal, or frankly elevated, according to international guidelines.
In this context, a panel of experts, organized and coordinated by the Nutrition Foundation of Italy, has evaluated the nutritional and lifestyle interventions to be adopted in the control of plasma cholesterol levels (and specifically of LDL cholesterol levels). This Consensus document summarizes the view of the panel on this topic, with the aim to provide an updated support to clinicians and other health professionals involved in cardiovascular prevention.Poli A, Marangoni F, Paoletti R, Mannarino E, Lupattelli G, Notarbartolo A, Aureli P, Bernini F, Cicero A, Gaddi A, Catapano A, Cricelli C, Gattone M, Marrocco W, Porrini M, Stella R, Vanotti A, Volpe M, Volpe R, Cannella C, Pinto A, Del Toma E, La Vecchia C, Tavani A, Manzato E, Riccardi G, Sirtori C, Zambon A; Nutrition Foundation of Italy: Nutr Metab Cardiovasc Dis. 2008 Feb;18(2):S1-16. Epub 2008 Feb 7. An analysis of peroxisome proliferator-activated receptor gamma (PPAR-gamma 2) Pro12Ala polymorphism distribution and prevalence of type 2 diabetes mellitus (T2DM) in world populations in relation to dietary habits.BACKGROUND AND AIM: The human peroxisome proliferator-activated receptor gamma (PPAR-gamma) is involved in lipid storage, glucose homeostasis and adipocyte differentiation.
The Ala allele of the Pro12Ala polymorphism has been associated with a protective effect against T2DM. Ala allele frequencies are known for many populations, but data are absent for other interesting human groups.METHODS AND RESULTS: We examined samples from Ethiopia, Benin, Ecuador and Italy. In addition, we performed an analysis of the Pro12Ala polymorphism distribution in world populations, also in relation to T2DM prevalence and the diet lipid content. In the European populations, the Ala allele frequencies are distributed according to a latitudinal trend, with the highest in the northern and central European populations and the lowest in the Mediterranean populations. Considering the world populations, a significant inverse relationship between Ala frequency and T2DM prevalence was observed mainly in populations where energy from lipids exceeded 30% of the total energy intake.CONCLUSION: Northern Europe's cold climate has been hypothesised to have played a role in contributing to the present pattern. Moreover our analysis appears to confirm, at a population level, the protective effect of Ala allele against T2DM, already observed in case-control studies, but only in populations with a diet rich in lipids.Scacchi R, Pinto A, Rickards O, Pacella A, De Stefano GF, Cannella C, Corbo RM: Nutr Metab Cardiovasc Dis. 2007 Nov;17(9):632-41.
Epub 2007 Apr 16.